Amino and nitro containing tricyclic compounds useful as inhibit

Details Amino and nitro containing tricyclic compounds useful as inhibit Amino and nitro containing tricyclic compounds useful as inhibit

1992-06-25

1993-05-04

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540521, 540522, A61K 3155, C07D47104, C07D48704, C07D49804

Patent

active

052082300

ABSTRACT:
The present invention relates to compounds of the formula ##STR1## wherein A is methylene, oxygen, sulfur or N-B wherein B is R.sub.1 or COR.sub.2 wherein R.sub.1 is hydrogen, a C.sub.1 -C.sub.4 alkyl or an Ar--Z-- group wherein Ar is aryl and Z is a C.sub.0 -C.sub.4 alkyl and R.sub.2 is a --CF.sub.3, a C.sub.1 -C.sub.10 alkyl or an Ar--Z group;

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Attwood, et al., J. Chem. Soc., Perkin Trans I, 1011-1019 (1986).
Natoff, et al., Drugs of the Future 12(5):475-483 (1987).
Flynn et al.: J. Am. Chem. Soc. 109,7914 (1987).
Flynn et al.: Peptide Chemistry 1987: T. Shiba & S. Sakakibara (Ed.), Protein Research Foundation, Osaka (1988).
Flynn, et al., "The Conversion of a diazolactam to an .alpha.-methylenelactam: an entrance to new conformationally restricted inhibitors of angiotensin-converting enzyme", Tetrahedron Letters, vol. 31, No. 6, pp. 815-818, 1990.

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