Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Reexamination Certificate
2003-06-16
2008-10-21
Davis, Brian J (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
C564S341000, C564S384000, C564S442000, C558S488000, C556S422000
Reexamination Certificate
active
07439400
ABSTRACT:
The invention disclosed a new process of asymmetric alkynylation of ketone or ketimine, involving the chiral ligand-mediated asymmetric addition of zinc or copper acetylide to a trifluoromethyl ketone or ketimine intermediate to give a chiral tertiary proparglic alcohols or amines. The adduct compounds include the key precursors to the potent HIV reverse transcriptase inhibitor Efavirenz (DMP 266), DPC 961 and DPC 083. The invention also disclosed a novel chiral amino alcohol ligand.
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Jiang Biao
Si Yugui
Davis Brian J
Li Manni
Perkins Coie LLP
Shanghai Institute of Organic Chemistry, Chinese Academy of Scie
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