Amino alcohol derivatives, pharmaceutical compositions...

Details Amino alcohol derivatives, pharmaceutical compositions... Amino alcohol derivatives, pharmaceutical compositions...

2008-09-09

2008-09-09

Eyler, Yvonne (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C568S586000, C514S646000

Reexamination Certificate

active

10545380

ABSTRACT:
The present invention provides compounds represented by general formula (I):or pharmaceutical acceptable salts thereof, wherein R1and R2are each hydrogen or lower alkyl; R3, R4, R5and R6are each hydrogen, halogen, lower alkyl or lower alkoxy; R7and R8are each hydrogen, halogen, lower alkyl, halo-lower alkyl, lower alkoxy, cycloalkyl, aryl, heteroaryl, cyano, a hydroxyl group, lower acyl, carboxy or the like; R9is —C(O)—R10, -A1-C(O)—R10, —O-A2-C(O)—R10or a tetrazol-5-yl group, which exhibit potent and selective β3-adrenoceptor stimulating activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.

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Bristol, Annual Reports in Medicinal Chemistry. 1998, vol. 33, pp. 193-202.
Arbeeny, Obesity Research, 2004, vol. 12, No. 8, pp. 1191-1196.

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