Amino alcohol derivative and method for preparing the same

Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

546246, 546247, 548566, 548567, 548569, 548950, 548967, C07D20712, C07D20714, C07D21112, C07D22304

Patent

active

059070390

ABSTRACT:
Amino alcohol derivatives with a primary amino group or a substituted amino group influence the synthesis of glycolipids and have antiviral, antitumor, metastasis inhibiting and neural cell growth enhancing functions. The amino alcohol derivatives are useful in preparing 2-acylamino alcohol derivatives.

REFERENCES:
patent: 5041441 (1991-08-01), Radin et al.
Jin-ichi Inokuchi et al., "Preparation of the Active Isomer of 1-phenyl-2-decanoylamino-3-morpholino-1-propanol, inhibitor of murine glucocerebroside synthetase" J. of Lipid Research, 28:565-571 (1987).
Akira Abe et al., "Structural and stereochemical studies of potent inhibitors of glucosylceramide synthase and tumor cell growth" J. of Lipid Research, 36:611-621 (1995).
Norman S. Radin et al., "Metabolic Effects of Inhibiting Glycoslyceramide Synthesis with PDMP and Other Substance" Advances of Lipid Research 26:183-213 (1993).
Quanying Liu et al. "Lewis Acid Induced Rearrangement of 2,3-Epoxy Amines; Characterisation of Aziridinium Ion Intermediates and Regiospecific Ring Opening with Nitrogen Nucleophiles", J. Chem. Soc. Perkin Trans. 1:1363-1365 (1994).
Williams et al. "Syntheses of some substituted 1-phenyl-2,3-diamino-1-propanols from .alpha.-halogen substituted Mannich bases", J. of the Am. Chem. Soc., 74(15):3875-3877 (1952).
Bruce A. Fenderson et al. "A Ceramide Analogue (PMDP) Inhibits Glycolipid synthesis in Fish Embryos" Experimental Cell Research, 198(2):362-366 (1992).
R.R. Vunnam et al. "A New Class of Monoamine Oxidase Inhibitors", J. of Neurochemistry, 34(2):410-416, (1980).
Robin Polt et al. "Aluminoxy Acetals from .alpha.-Amino esters: Chirality Transfer via Sequential Addition of Hydride and C-Nucleophiles. 2-Amino Alcohols and Sphingosines", J. Org. Chem., 57(20):5469-5480, (1992).
Manfred E. Wolff et al. "Synthesis of Some 1-Phenyl-2-amino-3-substituted-amino-1-propanols from .alpha.-Oximino Mannich Bases", J. of the Am. Chem Soc., 78:(11)2615:2618, (1956).
Akira Abe et al. "Improved Inhibitors of Glucosylceramide Synthase" J. Biochem. 111:191-196 (1992).
Gerald Brenner-Weib et al. "Synthesis of Potential Inhibitors of the Glycosphingolipid Biosynthesis" Tetrahedron Letter 48(28):5855-5860 (1992).
Kenneth G. Carson et al. "Studies on Morpholinosphingolipids Potent Inhibitors of Glycosylceramide Synthase" Tetrahedron Letters 35(17):2659-2662 (1994).
Norman S. Radin et al. "Metabolic Effects of Inhibiting Glycosylceramide Synthesis with PDMP and Other Substance" Advances of Lipid Research 26:183-213 (1993).
CA 51:3495, Chemical Abstracts, Mar. 1957.
CA 51:1190, Chemical Abstracts, Jan. 1957.
CA 107:7603, Chemical Abstracts, Abstract for JP 61145148, 1987.
Loudon, Solid-Phase Peptide Synthesis, Organic Chemistry, pp. 1347-1352, 1984.
Morrison et al., Organic Chemistry, Fourth Edition, pp. 206 and 902-903, 1987.
Fieser et al., Reagents for Organic Synthesis, pp. 109-110, 1967.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Amino alcohol derivative and method for preparing the same does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Amino alcohol derivative and method for preparing the same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Amino alcohol derivative and method for preparing the same will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-401743

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.