Amino acids containing dihydropyridine ring systems for site-spe

Details Amino acids containing dihydropyridine ring systems for site-spe Amino acids containing dihydropyridine ring systems for site-spe

1987-04-07

1989-12-19

Fan, Jane T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546287, 546286, 546288, 546176, 546175, 546146, 546169, 546177, 546167, 546153, 546170, 546321, 546318, 546323, 546328, 546335, C07D21186

Patent

active

048884278

ABSTRACT:
The invention provides novel amino acids and peptides containing them which comprise a dihydropyridine.revreaction.pyridinium salt-type redox system and which provide site-specific and sustained delivery of pharmacologically active peptides to the brain. These new amino acids contain a redox system appended directly or via an alkylene bridge to the carbon atom adjacent to the carboxyl carbon and may be incorporated into a peptide chain at a variety of positions, including non-terminal positions.

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