Amino acid-substituted coagulation factor V

Details Amino acid-substituted coagulation factor V Amino acid-substituted coagulation factor V

2006-01-23

2010-02-23

Robinson, Hope A (Department: 1652)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C530S300000

Reexamination Certificate

active

07666990

ABSTRACT:
There is provided FV derivatives that reduce blood clotting activity, by reducing thrombin generation, when compared to wild-type FV. In particular, the FV of the present invention comprises single-point and multi-point mutations, encompassed by aspartic acid 79 to glutamic acid 119 of the wild type sequence (SEQ ID NO:2). The derivatives can be used to treat patient with conditions necessitating reduced clotting activity.

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Adams, Ty E. et al., PNAS, 101(24):8918-8923 (2004). “The crystal structure of activated protein C-inactivated bovine factor Va: Implications for cofactor function.”

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