Amino acid sites in Flavivirus E proteins useful for...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof

Reexamination Certificate

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C424S186100, C435S005000

Reexamination Certificate

active

07943148

ABSTRACT:
Highly immunoreactive viral peptides are disclosed which are derived from the E protein of major groups of the Flavivirus genus by computational analyses. These peptides are used in reliable diagnostic methods for the detection and diagnosis of Flavivirus, detecting the presence of antibodies against Flavivirus, and to form vaccine composition(s) for the prevention of Flavivirus infections in humans.

REFERENCES:
patent: 7416733 (2008-08-01), Garry et al.
patent: 2004/0253578 (2004-12-01), Roberts et al.
Wong et al. Detection of human anti-flavivirus antibodies with a west nile virus recombinant antigen microsphere immunoassay. J Clin Microbiol. Jan. 2004;42(1):65-72.
Leyssen et al. Perspectives for the Treatment of Infections with Flaviviridae. J Clin Microbiol. Jan. 2000; 13(1): 67-87.

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