Amino acid sequences of anti-idiotypic antibodies against anti-c

Details Amino acid sequences of anti-idiotypic antibodies against anti-c Amino acid sequences of anti-idiotypic antibodies against anti-c

1994-10-06

1996-12-31

Adams, Donald E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

5303871, 5303873, 536 2553, C07K 1642, A61K 5110

Patent

active

055895735

ABSTRACT:
Amino acid sequences of the H chain and L chain variable regions of mouse monoclonal antibodies Idio 3, Idio 17, Idio 20, Idio 27 and Idio 33 against idiotypes of a cancer cell antigen-specific human immunoglobulin CLN/IgG produced by a human/human fused cell strain CLN/SUZ H11, and base sequences of the genes of the variable regions are disclosed. The above amino acid sequences and the base sequences are useful in medical and pharmaceutical fields such as prophylaxis, treatment and/or diagnosis of human diseases, and/or in pharmacological and/or biochemical fields, etc. such as biochemical reagents, and reagents for purification of biomacromolecules.

REFERENCES:
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Quantitation of human . . . , W. Taddei-Peters, et al., Cancer Research, vol. 52, No. 9, 1 May 1992, pp. 2603-2609.
Immunoglobulin variable region . . . , K. Yago, et al., Molecular Immunology, vol. 30, No. 16, Nov. 1993, pp. 1481-1489.

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