Amino acid formulations for patients with liver disease and meth

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...

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424274, 424319, A61K 31415, A61K 3140, A61K 31195

Patent

active

039505294

ABSTRACT:
Amino acid formulations for administration to human patients with liver disease comprise mixtures of essential amino acids combined in novel relative proportions, and preferably also include non-essential amino acids. In particular, the combined molar proportions of isoleucine, leucine, and valine are from 40 to 300 times the molar proportion of tryptophan and from 15 to 135 times the molar proportion of phenylalanine, or phenylalanine and tyrosine. The formulations may be adapted for either intravenous or oral administration, but the preferred method of administration is by hyperalimentation infusion. The formulations and method can be utilized to provide nutritional support for liver diseased patients while reducing the incidence and severity of hepatic encephalopathy, and/or as primary therapy for treatment of hepatic encephalopathy.

REFERENCES:
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patent: 3256095 (1966-06-01), Crosby
patent: 3697287 (1972-10-01), Winitz
patent: 3764703 (1973-10-01), Bergstrom et al.
patent: 3773930 (1973-11-01), Mohammed et al.
patent: 3793450 (1974-02-01), Schnell

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