Amino acid derivatives with angiotensin II antagonist properties

Details Amino acid derivatives with angiotensin II antagonist properties Amino acid derivatives with angiotensin II antagonist properties

1990-05-25

1991-08-20

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

5482642, 5482668, 5482678, C07D24908

Patent

active

050415522

ABSTRACT:
This invention relates to novel amino acid derivatives which antagonize the binding of angiotensin II to its receptors. The compounds are useful in the treatment of hypertension, heart failure, glaucoma, and hyperaldosteronism. Methods of making the compounds, novel intermediates useful in the separation of the compounds, compositions containing the compounds and methods of using them are also covered.

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