Amino acid derivatives which have renin inhibiting activity

Details Amino acid derivatives which have renin inhibiting activity Amino acid derivatives which have renin inhibiting activity

1990-03-29

1992-08-18

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 530331, 548215, 548218, 549321, 549322, 562443, 562445, 562448, 564153, A61K 3702, C07K 100, C07K 506, C07K 508

Patent

active

051400111

ABSTRACT:
The compounds of the formula ##STR1## wherein A, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the significance given in claim 1, in the form of optically pure diastereomers, mixtures of diastereomers, diastereomeric racemates or mixtures of diastereomeric racemates as well as pharmaceutically usable salts thereof inhibit the activity of the natural enzyme renin and can accordingly be used in the form of pharmaceutical preparations in the control or prevention of high blood pressure and cardiac insufficiency.

REFERENCES:
patent: 4613676 (1986-09-01), Fuhrer et al.
patent: 4652551 (1987-03-01), Luby et al.
patent: 4713445 (1987-12-01), Szelke et al.
patent: 4727060 (1988-02-01), Buhlmayer et al.
patent: 4758584 (1988-07-01), Buhlmayer et al.
patent: 4851387 (1989-07-01), Kaike et al.
patent: 4880781 (1989-11-01), Hester, Jr. et al.
Buhlmayer et al, "Synthesis and Biological Activity of Some Transition-State Inhibitors of Human Renin", J. Med. Chem, vol. 31, No. 9, 1988, pp. 1839-1846.
Luly et al, "Resin Inhibitors. Dipeptide Analogues of Angiotensin Utilizing . . . ", J. Med. Chem, vol. 31, No. 12, 1988, pp. 2264-2276.
Burger, Medicinal Chemistry, 1960, pp. 565-571, 578-581, 600-601.
Plattner et al. J. Med. Chem. 1988, 31(12):2277-2288.
Bolis et al. J. Med. Chem. 1987, 30(10):1729-1737.
Haber et al. J. Cardiovasc. Pharmacol. 1987, 10(Suppl. 7):554-558.

Affiliated with

Also associated with

Rating

Amino acid derivatives which have renin inhibiting activity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Amino acid derivatives which have renin inhibiting activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Amino acid derivatives which have renin inhibiting activity will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1249148