Amino acid derivatives useful to treat stroke

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514315, 514357, 514397, 514406, 514415, 514424, 514461, 514468, 514486, 514548, 514549, 514616, 514618, 514108, 514119, 514471, 514472, 514506, A61K 31445, A61K 3134

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active

061332615

ABSTRACT:
The invention provides a therapeutic method for treating or preventing stroke and other ischemic disorders, as well as novel compounds and pharmaceutical compositions useful for carrying out such methods.

REFERENCES:
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patent: 5654301 (1997-08-01), Kohn et al.
Bardel, P., et al., "Synthesis and Anticonvulsant Activities of .alpha.-Acetamido-N-benzylacetamide Derivatives Containing an Electron-Deficient .alpha.-Heteroaromatic Substituent", Journal of Medicinal Chemistry, vol. 37, pp.4567-4571, (1994).
Choi, D., et al., "Synthesis and Anticonvulsant Activities of N-Benzyl-2-acetamidopropionamide Derivites", Journal of Medicinal Chemistry, vol. 39, pp. 1907-1916, (1996).
Kohn, H., et al., Preparation and Anticonvulsant Activity of a Series of Functionalized .alpha.-Aromatic and .alpha.-Heteroaromatic Amino Acids, Journal of Medicinal Chemistry, vol. 33, pp. 919-926, (1990).

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