Amino acid derivatives useful as renin inhibitors

Details Amino acid derivatives useful as renin inhibitors Amino acid derivatives useful as renin inhibitors

1992-11-05

1994-01-11

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514248, 514300, 514303, 544236, 544350, 544405, 546119, 546121, 546336, 548215, 564374, 564453, C07D48704, C07D47104, C07D26306, A61K 31495

Patent

active

052781615

ABSTRACT:
Compounds of the formula ##STR1## wherein A, B, X, Y, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as set forth in the specification, in the form of optically pure diastereomers, mixtures of diastereomers, diastereomeric racemates or mixtures of diasteromeric racemates as well as pharmaceutically acceptable salts thereof which inhibit the activity of the natural enzyme renin and are useful in the control or prevention of high blood pressure and cardiac insufficiency are described.

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