Amino acid derivatives, processes for the manufacture thereof an

Details Amino acid derivatives, processes for the manufacture thereof an Amino acid derivatives, processes for the manufacture thereof an

1993-09-02

1997-01-21

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514221, 514290, 514253, 514414, 514218, 540523, 540575, 540553, 544373, 544372, 546101, 546158, 548468, 548482, 548493, A61K 3147, A61K 31415

Patent

active

055960006

ABSTRACT:
The invention relates to new amino acid derivatives of general formula I ##STR1## and the pharmaceutically acceptable salts thereof, wherein group B is --A.sup.2 --NR.sup.2 R.sup.3 or R.sup.5, wherein group R.sup.5 is ##STR2## and R.sup.1, A.sup.1, A.sup.2, R.sup.2, R.sup.3, R.sup.6, R.sup.7, R.sup.8, R.sup.9, X, Y, Z, t and u have the meanings described in the specification, as well as the preparation and use thereof. The novel compounds are valuable neurokinin (tachykinin) antagonists.

REFERENCES:
patent: 5104884 (1992-04-01), Korodi et al.

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