Amino acid derivatives, processes for the manufacture thereof an

Details Amino acid derivatives, processes for the manufacture thereof an Amino acid derivatives, processes for the manufacture thereof an

1995-06-05

1998-12-15

Sham, Munkund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546158, C07D21516, C07D21520, C07D21536

Patent

active

058499180

ABSTRACT:
The invention relates to new amino acid derivatives of general formula I ##STR1## and the pharmaceutically acceptable salts thereof, wherein group B is --A.sup.2 --NR.sup.2 R.sup.3 or R.sup.5, wherein group R.sup.5 is ##STR2## and R.sup.1, A.sup.1, A.sup.2, R.sup.2, R.sup.3, R.sup.6, R.sup.7, R.sup.8, R.sup.9, X, Y, Z, t and u have the meanings described in the specification, as well as the preparation and use thereof. The novel compounds are valuable neurokinin (tachykinin) antagonists.

REFERENCES:
Goldstein et al., Lett Pept. Sci. (1995), 2(3/4), 125-34, 1995.

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