Amino acid derivatives, processes for preparing them and pharmac

Details Amino acid derivatives, processes for preparing them and pharmac Amino acid derivatives, processes for preparing them and pharmac

1995-06-06

1998-01-27

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546110, 546158, C07D49156, C07D22106, C07D215227

Patent

active

057123977

ABSTRACT:
The invention relates to new amino acid derivatives of general formula I ##STR1## and the pharmaceutically acceptable salts thereof, wherein the group R.sup.2 is ##STR2## and R.sup.1, A, G, Y, Z and m have the meanings given in the specification, and the preparation and use thereof. The new compounds are valuable neurokinin (tachykinin)-antagonists.

REFERENCES:
patent: 4692522 (1987-09-01), Parsons
patent: 5162339 (1992-11-01), Lowe, III
patent: 5472978 (1995-12-01), Baker
"A Nonpeptidyl Growth Hormone Secretagogue"--Science--vol. 260, Jun. 11, 1993, pp. 1640-1643.
Vaught, JL (1988) Life Sci. 43, 1419-31.

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