Amino acid derivatives of paclitaxel

Details Amino acid derivatives of paclitaxel Amino acid derivatives of paclitaxel

1994-12-07

1996-02-06

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514210, 514253, 514422, 514449, 5142282, 544147, 544375, 544 587, 548525, 548950, 548964, 549510, A61K 31335, A61K 31535, C07D30514, C07D41312

Patent

active

054895898

ABSTRACT:
The present invention concerns water-soluble amino acid derivatives of paclitaxel, their use as antitumor agents, and pharmaceutical compositions containg the compounds.

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Nicholas Bodor and James J. Kaminski, "Chapter 30. Prodrugs and Site-Specific Chemical Delivery Systems", Annual Reports In Medicinal Chemistry, 22, pp. 303-312, 1987.
H. M. Deutsch, et al, "Synthesis of Congeners and Prodrugs. 3..sub.1 Water-Soluble Prodrugs of Taxol with Potent Antitumor Activity", J. Med. Chem., 32, pp. 788-792, 1989.
Michael Hepperie and Gunda I. Georg, "Taxol Analogs", Drugs Of The Future, 19(6), pp. 573-584, 1994.
Abraham E. Mathew, et al, "Synthesis and Evaluation of Some Water-Soluble Prodrugs and Derivatives of Taxol with Antitumor Activity", J. Med Chem., 35, pp. 145-151, 1992.
Kyriacos C. Nicolaou, et al, "Chemistry and Biology of Taxol", Angew. Chem. Int. Ed. Engl., 33, pp. 15-44, 1994.
S. A. Varia, et al, "Phenytoin Prodrugs IV: Hydrolysis of Various 3-(Hydroxymethyl)phenytoin Esters", Journal Of Pharmaceutical Sciences, 73, No. 8, pp. 1074-1080, Aug., 1984.

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