Amino acid derivatives of chloromethylated polymers and methods

Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Polymers from only ethylenic monomers or processes of...

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260 21E, 260 22R, 260 78A, 260 7841, 526 13, 526 46, 526 49, 526 50, 526339, C08F22208

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039706036

ABSTRACT:
The application discloses polymers and methods of making same in which a chlorine atom of a chloromethyl pendant group of a polymer such as a chloromethylated copolymer of styrene and divinylbenzene is substituted with a derivative of malonic acid having a protected amino group on the alpha-carbon atom and two carboxyl groups or precursors thereof to form, via several steps, the alpha-amino acid derivative of the starting polymer. These polymers are used, for instance, as ion exchange resins, as substrates for affinity chromotography, and as a starting resin for solid peptide synthesis. The resultant polymer is also used as a starting material to make a polymer with a pendant group that is a derivative of oxazolidone-2,5-dione, substituted at the 4-position. These polymers are used, for example, as the matrix for solid phase peptide synthesis and as the starting resin for solid phase peptide degradation.

REFERENCES:
Flory--Principles of Polymer Chemistry, 1953, pp. 75-78, 102-103.
Journal of the American Chemical Society, vol. 67, (1945), pp. 502-503.

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