Amino acid derivatives of chloromethylated polymers and methods

Details Amino acid derivatives of chloromethylated polymers and methods Amino acid derivatives of chloromethylated polymers and methods

1974-10-15

1976-07-20

Anderson, Harold D.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Polymers from only ethylenic monomers or processes of...

260 21E, 260 22R, 260 78A, 260 7841, 526 13, 526 46, 526 49, 526 50, 526339, C08F22208

Patent

active

039706036

ABSTRACT:
The application discloses polymers and methods of making same in which a chlorine atom of a chloromethyl pendant group of a polymer such as a chloromethylated copolymer of styrene and divinylbenzene is substituted with a derivative of malonic acid having a protected amino group on the alpha-carbon atom and two carboxyl groups or precursors thereof to form, via several steps, the alpha-amino acid derivative of the starting polymer. These polymers are used, for instance, as ion exchange resins, as substrates for affinity chromotography, and as a starting resin for solid peptide synthesis. The resultant polymer is also used as a starting material to make a polymer with a pendant group that is a derivative of oxazolidone-2,5-dione, substituted at the 4-position. These polymers are used, for example, as the matrix for solid phase peptide synthesis and as the starting resin for solid phase peptide degradation.

REFERENCES:
Flory--Principles of Polymer Chemistry, 1953, pp. 75-78, 102-103.
Journal of the American Chemical Society, vol. 67, (1945), pp. 502-503.

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