Amino acid derivatives, methods of preparing said derivatives an

Details Amino acid derivatives, methods of preparing said derivatives an Amino acid derivatives, methods of preparing said derivatives an

1984-03-16

1986-05-20

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530331, A61K 3700, C07C10352

Patent

active

045901783

ABSTRACT:
The present invention relates to an amino acid derivative represented by the formula ##STR1## wherein R.sub.1 and R.sub.2 represent hydroxyl, alkyloxy, aryloxy, arylkyloxy, alkyl, aryl, or aralkyl; R.sub.3, R.sub.5, R.sub.8 and R.sub.11 are hydrogen or alkyl; R.sub.4, R.sub.7 and R.sub.10 are hydrogen, or substituted or unsubstituted alkyl, aryl or aralkyl; R.sub.6 and R.sub.9 are hydrogen, alkyl, aryl, or aralkyl; R.sub.12 is hydroxyl, alkyloxy, aryloxy, aralkyloxy, amino, mono- or di-alkyl-, aryl- or aralkyl amino; and R.sub.6 and R.sub.7 combined together, and R.sub.9 and R.sub.10 combined together independently may form a substituted or unsubstituted alkylene bridge. The present invention also relates to a method of preparing said amino acid derivatives, and to anti-hypertensive drugs containing them.

REFERENCES:
patent: 4432971 (1984-02-01), Karanewsky et al.
patent: 4432972 (1984-02-01), Karanewsky et al.
patent: 4472381 (1984-09-01), Sakakibara et al.
Kenner et al, Tetrahedron Letters, No. 40, pp. 3623-3636 (1976).
Nishino and Powers, Biochemistry, vol. 18 (20): 4340-4347 (1979).

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