Amino acid derivatives having renin inhibiting activity

Details Amino acid derivatives having renin inhibiting activity Amino acid derivatives having renin inhibiting activity

1994-07-19

1997-11-18

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

514326, 514397, 514380, 514399, 514400, 514616, 514 18, 514 19, 514394, 5142315, 546138, 548215, 5483381, 5483391, 5483061, C07D29512, C07D29522, A61K 3195, A61K 3700

Patent

active

056889461

ABSTRACT:
The compounds of the formula ##STR1## in the form of optically pure diastereomers, mixtures of diastereomers, diastereomeric racemates or mixtures of diastereomeric racemates as well as pharmaceutically usable salts thereof inhibit the activity of the natural enzyme renin and can accordingly be used in the form of pharmaceutical preparations in the control or prevention of high blood pressure and cardiac insufficiency.

REFERENCES:
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patent: 4845079 (1989-07-01), Luly et al.
patent: 5032577 (1991-07-01), Fung et al.
patent: 5134123 (1992-07-01), Branca et al.
Burger, A. Medicinal Chemistry, 2nd Ed., pp. 565-571, 578-81, 600-601 (1960).
Denkewalter et al., Progress in Drug Research, vol. 10, pp. 510-512 (1966).
Bolis et al., J. Med. Chem, vol. 30, pp. 1729-1737 (1987).
Haber et al., J. Cardiovascular Pharmacology, vol. 10 (Supp. 7), S54-S58 (1987).
Plattner et al., J. Med. Chem., vol. 31, pp. 2277-2288 (1988).

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