Amino acid derivatives having renin inhibiting activity

Details Amino acid derivatives having renin inhibiting activity Amino acid derivatives having renin inhibiting activity

1993-08-03

1995-02-28

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 187, 5483151, 5483147, 5483111, 5483315, 5483385, 5483657, 5483641, 5483751, C07C31744, A61K 3700, A61K 31415, C07D29512

Patent

active

053938755

ABSTRACT:
The compounds of the formula ##STR1## wherein A, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the significance given in claim 1,
in the form of optically pure diastereomers, mixtures of diastereomers, diastereomeric racemates or mixtures of diastereomeric racemates as well as pharmaceutically usable salts thereof inhibit the activity of the natural enzyme renin and can accordingly be used in the form of pharamaceutical preparations in the control or prevention of high blood pressure and cardiac insufficiency. They can be manufactured according to various methods which are known per se.

REFERENCES:
patent: 4902706 (1990-02-01), Hanson et al.
patent: 5134123 (1992-07-01), Branca et al.
English Abstract of EP# 0 309 841.
Burger, Medicinal Chemistry, 1960, pp. 565-571, 578-581, 600 & 601.
Plattner et al., J. Med. Chem., 1988, 31(12), pp. 2277-2288.
Denkewalter et al., Progress in Drug Research, 1966, vol. 10, pp. 510-512.
Haber et al., J. Cardiovasc. Pharmacol., 1987, 10 (Supp. 7), pp. S54-S58.
Bolis et al., J. Med. Chem., 1987, 30 (10), pp. 1729-1737.

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