Amino acid derivatives having anti-tumor activity and compositio

Details Amino acid derivatives having anti-tumor activity and compositio Amino acid derivatives having anti-tumor activity and compositio

1988-01-22

1990-02-27

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546280, 548200, 548567, 548568, 564 92, 564155, C07D27706, A61K 31425

Patent

active

049046802

ABSTRACT:
Amino acid amides of formula (I): ##STR1## wherein R.sup.1 -R.sup.5 and Y represent a variety of organic groups and atoms (including where R.sup.2, Y and the adjacent nitrogen atom together represent a thiazolidine or pyrrolidine group) and X represents carbonyl or sulfonyl are mostly new compounds and have valuable anti-tumor and immuno-regulatory activities. They may be formulated in compositions for pharmaceutical use.

REFERENCES:
Baldwin et al, JACS 97, 5957 (1975).
Chemical Abstracts, vol. 98, May 23-Jun. 6, 1983.
Analytical Chemistry, vol. 56, May 1984.

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