Amino acid derivatives and application thereof

Details Amino acid derivatives and application thereof Amino acid derivatives and application thereof

1995-02-22

1998-06-09

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

A61K 3803

Patent

active

057634084

ABSTRACT:
There are disclosed amino acid derivatives represented by the following general formula (I): ##STR1## wherein L.sup.1 and L.sup.2 represent an amino acid residue etc., A.sup.1 and A.sup.3 represent C.dbd.O, A.sup.2 represents an alkylene group etc., m and n represent an integer of 1 to 5, V represents --NHC(.dbd.NH)NH.sub.2 etc., W represents --COOH etc., R.sup.1 and R.sup.2 represent hydrogen atom, alkyl group etc., R.sup.3 and R.sup.4 represent hydrogen etc. and X and Y represent --NH-- or --O-- and pharmaceutically acceptable salts thereof and agents for inhibiting tumor matastasis containing the compounds, and the amino acid derivatives exhibit high activity for inhibiting tumor metastasis and weak platelet aggregation inhibition activity and weak anticoagulation activity.

REFERENCES:
Pierschbachel et al., "Influence Stereochemistry R-G-D-X.sub.xa on Binding in Cell Adhesion", J. Biol. Chem., v. 262, N. 36, pp. 17294-17298. (1987).
Goodman et al., "Concept of Linear Modified Retro-Peptide stimulants", All. Chem. Res., v. 12, N. 1, pp. 1-7. (1979).
Ali et al., "Anti Aggregatory Peptides" (20 Aug. 1992) Chem Abs 118:7397.

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