Amino acid derivatives

Details Amino acid derivatives Amino acid derivatives

2007-01-23

2007-01-23

Raymond, Richard L. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S227500, C514S357000, C514S365000, C514S374000, C514S399000, C514S448000, C544S054000, C544S058100, C544S058400, C546S323000, C548S200000, C548S236000, C548S333500, C549S072000

Reexamination Certificate

active

10154780

ABSTRACT:
A compound of the formula (I):[wherein R1is (substituted) alkyl, alkoxy, phenyl, hetero ring etc.; A is bond, CO, SO2; R2is H, (substituted) alkyl etc.; D is alkylene etc.; E is COO, OCO, O, S, SO, SO2etc.; R3is (substituted) alkyl, carbocyclic ring, hetero ring; J is O, NR16(R16is H, substituted alkyl); R4is (substituted) alkyl, carbocyclic ring, hetero ring.] or non-toxic salt thereof, and an N-type calcium channel blocker comprising it as an active ingredient.The compounds of the formula (I) possess an inhibitory action on N-type calcium channel, so they are useful as agent for the prevention and/or treatment of cerebral infarct, transient ischemic attack, encephalomyelopathy after cardiac operation, spinal angiopathy, hypertension with stress, neurosis or epilepsy etc. or agent for the treatment of pain.

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