Amino acid derivatives

Details Amino acid derivatives Amino acid derivatives

1995-04-20

1998-01-06

Trinh, Ba K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514343, 514365, 514399, 514400, 514419, 514459, 514509, 5462794, 548204, 548205, 5483381, 5483401, 548496, 548507, 549229, 549425, 549426, 549427, 558483, A61K 31335, A61K 3104, C07D31734, C07D20302

Patent

active

057055270

ABSTRACT:
An amino acid compound of the formula: R.sup.1 NH--CH(R.sup.2)--COHN--A--ONO.sub.2, wherein R.sup.1 represents a hydrogen atom, a C.sub.1 -C.sub.7 alkanoyl group, a C.sub.1 -C.sub.6 alkoxycarbonyl group, a C.sub.6 -C.sub.10 arylcarbonyl group, a C.sub.7 -C.sub.13 aralkylcarbonyl group, a C.sub.7 -C.sub.13 aralkyloxycarbonyl group or a 5- or 6-membered aromatic heterocyclic carbonyl group; R.sup.2 represents a substituted C.sub.1 -C.sub.6 alkyl group; and A represents a C.sub.2 -C.sub.5 alkylene group; and pharmacologically acceptable salts thereof. The amino acid compound has an excellent vasodilator action for collateral vessels and is useful for treating angina pectoris.

REFERENCES:
patent: 5037849 (1991-08-01), Simon et al.
patent: 5284872 (1994-02-01), Sandrock et al.

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