Amino acid derivatives

Details Amino acid derivatives Amino acid derivatives

1989-03-03

1992-07-28

Dees, Jose G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 514616, 548373, 548146, 548215, 548566, 544242, 546138, 549 74, 549491, A61K 3700

Patent

active

051341239

ABSTRACT:
The compounds of the formula ##STR1## wherein A, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are as set forth above, are described.
The compounds of formula I have an inhibitory activity on the natural enzyme renin and can accordingly be used in the form of pharmaceutical preparations for the control or prevention of high blood pressure and cardiac insufficiency.

REFERENCES:
patent: 4657931 (1987-04-01), Baran et al.
patent: 4680284 (1987-07-01), Luly et al.
Luly et al., Chemical Abstracts, vol. 111, p. 15, 1989.
Levy et al., Cardiovascular Research: Decades of Progress, A Decade of Promise Science, vol. 217, pp. 121-129, Jul. 9, 1982.
O'Malley et al., Biochemistry and Pharmacology of Hypertension, Biochem. Soc. Trans. 10(3), pp. 164-165 (1982).

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