Amino acid derivatives

Details Amino acid derivatives Amino acid derivatives

1990-11-19

1993-03-23

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514314, 546164, A61K 3147, C07D26530

Patent

active

051964384

ABSTRACT:
Compounds having the formula ##STR1## wherein R is benzyloxycarbonyl or 2-quinolylcarbonyl, and their pharmaceutically acceptable acid addition salts inhibit proteases of viral origin and can be used as medicaments for the treatment of prophylaxis of viral infections in mammals, humans or non-humans.

REFERENCES:
patent: 3901897 (1975-08-01), Hauck et al.
patent: 4123543 (1978-10-01), Jonsson et al.
patent: 4329473 (1982-05-01), Almquist et al.
patent: 4470973 (1984-09-01), Naterajan et al.
patent: 4720484 (1988-01-01), Vincent et al.
patent: 4812442 (1989-03-01), Boger et al.
patent: 4863905 (1989-09-01), Hudspeth et al.
patent: 4965250 (1990-10-01), Vincent et al.
Derwent Abstract of EPA 264106 (Apr. 20, 1988).
Derwent Abstract of EPA 292800 (Nov. 30, 1988).
Dewent Abstract of EPA 309841 (Apr. 20, 1989).
Derwent Abstract of EPA 342541 (Nov. 23, 1989).
Derwent Abstract of EPA 346847 (Dec. 20, 1989).
Derwent Abstract of WO88/00939 (Feb. 11, 1988).
Meek et al. "Inhibition of HIV-1 Protease . . . ", Nature, 343, 90 (Jan. 4, 1990).
McQuade "A Synthetic HIV-1 Protease Inhibitor . . . ", Science, 247, 454 (Jan. 26, 1990).
Dreyer "Inhibition of Human Immunodeficiency Virus 1 . . . ", Proc. Natl. Acad. Sci. USA, 86(24), 9752 (1989).
Frey "Lactone Precursor . . . ", J. Org. Chem., 51(25), 4828 (1986).
Jouin, "Synthesis . . . ", J. Org. Chem., 54(3), 617 (1989).
Harris, "Didemnins III", Tetrahedron, 44(12), 3489 (1988).
Overton "Effect", Virology, 179, 508 (1990).
Roberts, "Rational Design", Science, 248, 358 (Apr. 20, 1990).
Kotler, Proc. Natl. Acad. Sci. USA, 85, 4185 (1989).
Crumpaker, N. Engl. J. Med., 321, 163 (1989).
Genetic Engineering & Biotechnology Monitor, No. 33, 30 (1991).
Thayer, Chem. Eng. News, 23 Apr. 1990, p. 18.
CA102(19):166520u-1984.
Tetrahedron Letters, 25(51):5899-5902 (1984).

Affiliated with

Also associated with

Rating

Amino acid derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Amino acid derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Amino acid derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1351982