Amino acid derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514332, 514340, 514342, 514343, 514422, 546194, 546208, 546213, 546214, 546261, 546263, 546281, 546283, 546284, 548517, 548524, 548527, A61K 3144, C07D40106

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active

049314505

ABSTRACT:
Compounds of the Formula I ##STR1## wherein R.sup.1 represents phenyl, or phenyl substituted by one, or more substituents selected from the group consisting of halogen, C.sub.1-7 -alkyl, and C.sub.1-7 -alkoxy, R.sup.2 represents furanyl, thienyl, pyridyl or pyrrolyl ortho substituted with C.sub.1-7 -alkyl or halogen and wherein R.sup.3 represents 3-carboxypiperidin-1-yl, 3-carboxy-1,2,5,6-tetrahydropyridin-1-yl or 3-carboxymethyl-pyrrolidin-1-yl, pharmaceutical compositions containing effective amounts of a compound of formula I and treatment of central nervous system ailments by administering a compound of formula I.

REFERENCES:
patent: 4383999 (1983-05-01), Bondinell et al.
patent: 4681884 (1987-07-01), Grozinger et al.
Younger et al., "Chemical Abstracts", vol. 100, 1984, col. 100:114852t.
Sonnewald, "Chemical Abstracts", vol. 108, 1988, col. 108:167299q.

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