Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-04-10
1997-04-15
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514311, 514416, 546164, 546165, 546112, C07D21716, A61K 3147
Patent
active
056209878
ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, and --N(R.sup.7)--CH(R.sup.8)(R.sup.9) are as claimed herein or their pharmaceutically acceptable acid addition salts inhibit proteases of viral origin and can be used as medicaments for the treatment of viral infections. They can be manufactured according to generally known procedures.
REFERENCES:
patent: 4402969 (1983-09-01), Greenlee et al.
patent: 4470973 (1984-09-01), Natarajan et al.
patent: 4575503 (1986-03-01), Watthey
patent: 4621092 (1986-11-01), Natarajan et al.
patent: 4636522 (1987-01-01), Gordon
patent: 4638010 (1987-01-01), Weller et al.
patent: 4720484 (1988-01-01), Vincent et al.
patent: 4812442 (1989-03-01), Boger et al.
patent: 4863905 (1989-09-01), Hadspeth et al.
patent: 4965250 (1990-10-01), Vincent et al.
patent: 5008273 (1991-04-01), Schnorrenberg et al.
patent: 5157041 (1992-10-01), Handa et al.
patent: 5196438 (1993-03-01), Martin
C. S. Crumpacker, N. Engl. J. Med. 321:163-172 (1989).
J. Fuhrhop and G. Penzlin, Organic Synthesis: Concepts, Methods, Starting Materials (Verlag Chemie, Weinheim 1983) (Textbook).
M. Kotler, et al., Proc. Natl. Acad. Sci. USA 85:4185-89.
M. Miller, et al., Nature 337:576-79 (1989).
Genetic Engineering & Biotechnology Monitor, No. 33, 30 (1991).
Chem. Eng. News, 30 Apr. 1990, p. 18.
Meek, et al., Nature 343: 90-92 (1990).
McQuade, et al., Science 247:454-456 (1990).
Dreyer, et al., Proc. Natl. Acad. Sci. 86(24):9752-9756 (1989).
Jouin, et al., J. Org. Chem, 54(3):617-627 (1989).
Fray, et al., J. Org. Chem. 51(25):4828-4833 (1986).
Harris, et al., Tetrahedron 44(12):3489-3500 (1988).
Roberts, et al, Science 248:358-361 (1990).
Overton, et al., Virology 179:508-511 (1990).
Handa Balraj K.
Machin Peter J.
Martin Joseph A.
Redshaw Sally
Thomas Gareth J.
Hoffmann-La Roche Inc.
Ivy C. Warren
Johnston George W.
Kass Alan P.
M. Mach D. Margaret
LandOfFree
Amino acid derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Amino acid derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Amino acid derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-361023