Amino acid derivative, method for preparing the same and method

Details Amino acid derivative, method for preparing the same and method Amino acid derivative, method for preparing the same and method

1992-05-22

1993-11-02

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C07C26100

Patent

active

052585450

ABSTRACT:
There is disclosed a novel .gamma.-carboxyglutamic acid, a method for preparing the same and a method for preparing Gla.sup.17 human osteocalcin and Glu.sup.17 human osteocalcin or salts of these, which comprises introducing .gamma.-carboxyglutamic acid in a peptide synthetic method of human osteocalcin by use of a protected L-.gamma.-carboxyglutamic acid represented by the formula: ##STR1## wherein n represents 0, 1 or 2, or a salt thereof.

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Biological Abstracts, vol. 87, 1989, abstract No. 122392, L. Simionescu et al. "Methods of Isolation and Purification of Bovine and Rate Osteocalcin".
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Marki et al., Helvetica Chimica Acta 60:807-815, 1977.
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Danishefsky et al., J. Am. Chem. Soc. 101: 4385-4386, Jul. 18, 1979.
Barany et al. "Solid-Phase Peptide Synthesis", pp. 1-255, in The Peptides, Gross et al., editors, 1980.

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