Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1990-08-16
1992-11-24
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
552642, 552643, 552648, A61K 3156, C07J 100, C07J 900
Patent
active
051661462
ABSTRACT:
A compound of the formula ##STR1## wherein R.sub.1 is an aliphatic hydrocarbon of 1 to 8 carbon atoms, R.sub.a and R.sub.b are individually hydrogen or alkyl of 1 to 4 carbon atoms, R.sub.2 is hydrogen or optionally substituted alkyl of 1 to 12 carbon atoms, n is an integer from 1 to 6, Z is free carboxy or salified with an alkali metal, alkaline earth metal or NH.sub.4 and X is the remainder of an optionally substituted and optionally unsaturated 5 or 6-member ring and the wavy line indicates the .alpha.- or .beta.-position for R.sub.1 having anti-glucocorticoid activity.
REFERENCES:
Loozen et al., Chemical Abstract vol. 109, 1988 #CA 109(19): 170799.
Moguilewsky Martine
Nedelec Lucien
Nique Francois
Philibert Daniel
Gupta Y. N.
Rizzo Nicholas S.
Roussel Uclaf
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