Amino acid compositions and use thereof in treating renal dysfun

Details Amino acid compositions and use thereof in treating renal dysfun Amino acid compositions and use thereof in treating renal dysfun

1996-07-30

2000-08-01

Fay, Zohreh

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

A61K 3131

Patent

active

060967854

ABSTRACT:
A method for the use of at least one amino acid selected from the group consisting of glycine, alanine and serine, or the physiologically acceptable salts thereof (component (a)), in the preparation of a medicament or nutritional formulation for the prophylaxis and/or therapy of renal dysfunction induced by cyclosporins or ascomycins.

REFERENCES:
patent: 5290538 (1994-03-01), Bertermann
patent: 5656608 (1997-08-01), Schneider et al.
Cellular Proliferation and Macrophage Influx Precede Interstitial Fibrosis in Cyclosporine Nephrotoxicity, Kidney International, Young, et al., vol. 48, pp. 439-448, (1995).
Glycine Attenuates Fanconi Syndrome Induced by Maleate or Ifosfamide in Rats, Kidney International, Nissim, et al., vol. 49, pp. 684-695, (1996).
Nephrotoxicity of Immunosuppressive Drugs, Nephrology Dialysis Transplantation, Bennett, et al., vol. 9, (Suppl. 4), pp. 141-145 (1994).
De Nicola et al., J. Clin. Invest. vol. 92, No. 4, 1859-1865. Oct. 1993.
De Nicola, J. Am. Soc. Nephrol., vol. 2, No. 3, p. 47P, 1991.
Mobb, Renal Fail., vol. 17, No. 2, pp. 175-180, 1992.

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