Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Reexamination Certificate
2011-06-07
2011-06-07
Andres, Janet L (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
C564S123000
Reexamination Certificate
active
07956219
ABSTRACT:
In the present specification we describe a new class of compounds, designed to modulate the ability of blood vessels to synthesize NO from L-arginine. In particular we have identified novel compounds which enhance the entry of L-arginine into cells. These compounds improve endothelial function, and thereby have the potential to retard the progression of vascular disease in conditions such as hypertension, heart failure and diabetes. This new class of drugs may also have other potentially, relevant pharmacological actions, including anti-hypertensive and anti-anginal actions.
REFERENCES:
patent: 4293690 (1981-10-01), Sawa et al.
patent: 280182 (1952-04-01), None
patent: 172307 (1965-06-01), None
patent: 9531194 (1995-11-01), None
patent: WO 9531194 (1995-11-01), None
patent: WO9531194 (1995-11-01), None
Hcaplus 63:16263e-f.
Hcaplus 72:132260.
Hcaplus 1965:488647.
Hcaplus 1953:37791.
Hcaplus 124:185543.
Protective Groups in Organic Synthesis, Third Edition. Theodora W. Greene et. al., 1999, Chapter 7, pp. 503-653.
Hcaplus 107:23672.
Hcaplus 88:170131.
Adrian Marxer, “A New Bis-Guanylhydrazone with Antileukemic Properties”, Experientia (1967), 23 (3), 173-4.
Hcaplus 52:87901.
Patani et. al. “Bioisosterism: A Rational Approach in Drug Design”, Chem. Rev. 1996, 3147-3176.
Hcaplus 107:23672 abstract, “A facile conversion of amino acides to guanidino acids”, Miller et. al., 1986.
Hcaplus 88:170131 abstract, “Preventing and treating rhinovirus infections with thiazolylphenylguanidines”, 1977, American Cyanamid Co. as the Assignee.
Marxer, Adrian. “A new bis-guanylhydrazone with antileukemic properties”, Experientia, 1967, 23(3), 173-4.
Hcaplus 52:87901, “Some phenylthiourea derivatives and their antituberculous activity”, Doub et. al., (1958).
Ede Nicholas J.
Hunter Andrew N.
Kaye David M.
Trainor Robert W.
Andres Janet L
Baker IDI Heart and Diabetes
Rader & Fishman & Grauer, PLLC
Reese Heidi
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