Amino acid analogs as CCK antagonists

Details Amino acid analogs as CCK antagonists Amino acid analogs as CCK antagonists

1991-07-12

1994-07-19

Chang, Celia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

N-c doai

514487, 560 27, 560 28, A61K 3127, C07C27110

Patent

active

053310063

ABSTRACT:
Novel unnatural dipeptoids useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further, the compounds are antianxiety agents and antiulcer agents. The compounds are agents useful for preventing the response to withdrawal from chronic treatment or use of nicotine, diazepam, alcohol, cocaine, caffeine, and opioids. The compounds are also useful in treating and/or preventing panic attacks. Also disclosed are pharmaceutical compositions and methods of treatment using the dipeptoids as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject compounds to prepare diagnostic compositions.

REFERENCES:
patent: 4241064 (1980-12-01), Matsumura et al.
patent: 4705856 (1987-11-01), Biere
Thaisrivongs et al "Renin Inhibitory Peptides: A Study of Structural Modifications in the Peptide Backbone" CA 111:89774m (1989).

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