Amino acid amides of 1,3,4-thiadiazoles as matrix metalloprotein

Details Amino acid amides of 1,3,4-thiadiazoles as matrix metalloprotein Amino acid amides of 1,3,4-thiadiazoles as matrix metalloprotein

1995-06-07

1997-10-14

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 19, 514363, 514364, 530330, 530331, 548139, 548144, C07K 508, C07K 506, A61K 3141

Patent

active

056772823

ABSTRACT:
Amino acid amides of 5-amino-1,3,4-thiadiazole-2-thione are disclosed. These compounds inhibit matrix metalloproteinase enzymes and cartilage degradation. Methods of treating diseases caused by over-activity of matrix metalloproteinases, such as osteoarthritis and rheumatoid arthritis, are also disclosed.

REFERENCES:
Cho, N. S. and Kim, G. N., "Synthesis of 5-Aroylamino-3H-1,3,4-Thiadiazole-2-Thiones and Their Tautomerism," J. Heterocyclic Chem., 30:397 (1993).
Suiko, M., et al., "Relationship Between the Structures and Cytotoxic Chem., 46(11):2691-2695 (1982).

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