Amino acid 1,2-diketo derivatives as renin inhibitors

Details Amino acid 1,2-diketo derivatives as renin inhibitors Amino acid 1,2-diketo derivatives as renin inhibitors

1987-06-24

1989-04-11

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530331, 530332, 514 18, 540544, 540575, 540607, 544 584, 544168, 544390, 546245, 546336, 548200, 548215, 548341, 548494, 548538, 548540, 564157, 564159, A61K 3743, C07K 506, C07K 508, C07D27910, C07D26530, C07D24104, C07D21160, C07D21170

Patent

active

048206911

ABSTRACT:
Compounds of the formula ##STR1## are disclosed. These compounds interevene in the conversion of angiotensin to angiotensin II by inhibiting renin and thus are useful as anti-hypertensive agents.

REFERENCES:
Chem. Abstr., vol. 106, 85059.
Powers et al., "Inhibition of Human Leukocyte Elastase, Porcine Pancreatic Elastase and Cathepsin G by Pepside Ketones", Proceedings from the 9th American Peptide Symposium, Jun. 23-28, 1985, Univ. of Toronto, Canada.
Chem. Abstr., vol. 104, 22120u.
Chem. Abstr., vol. 89, 19797o.

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