Amino-3-substituted-methyl-3-cephem-4-carboxylic acid and lower

Details Amino-3-substituted-methyl-3-cephem-4-carboxylic acid and lower Amino-3-substituted-methyl-3-cephem-4-carboxylic acid and lower

1987-05-04

1989-07-04

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540225, 540222, C07D50138, A61K 31545

Patent

active

048452114

ABSTRACT:
Various 7-amino-3-substituted-methyl-3-cephem-4-carboxylic acids and lower alkylsily derivatives such as 7-amino-3-(2,3-cyclopenteno-1-pyridiniomethyl)-3-cephem-4 -carboxylic acid iodide and trimethylsilyl 7-trimethylsilylamino-3 -(5,6,7,8-tetrahydro-2-isoquinoliniomethyl)-3-cephem-4 -carboxylate iodide are valuable intermediates in the preparation of new and novel antibacterial agents. A new process for the preparation of these acids and the derivatives has been devised.

REFERENCES:
patent: 4407798 (1983-10-01), Kamiya et al.
patent: 4540779 (1985-09-01), Conrad et al.
patent: 4609653 (1986-09-01), Durckheimer
patent: 4665168 (1987-05-01), Chou et al.
patent: 4703118 (1987-10-01), Lord et al.

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