Amino-3 cardenolides, process for preparation, and pharmaceutica

Details Amino-3 cardenolides, process for preparation, and pharmaceutica Amino-3 cardenolides, process for preparation, and pharmaceutica

1979-01-26

1980-08-26

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

26023957, C07J 1900

Patent

active

042195497

ABSTRACT:
Aminocardenolides of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.4, R.sub.5, and R.sub.6, which may be the same or different, each represents a hydrogen atom or a hydroxy, alkoxy or acyloxy group; R.sub.3 represents a lower alkyl, hydroxyalkyl, acyloxyalkyl, haloalkyl or ethylenedioxyalkyl group; R.sub.7 represents a hydrogen atom, or an alkyl or acyl group, and R.sub.8 represents a hydrogen atom, an alkyl group or an amino acid residue; a process for preparation of the compounds with the above formula by reaction of an oxo-3 genin with an ammonium salt in the presence of a borocyanohydride in an organic solvent. The aminocardenolides of formula (I) are useful especially for the treatment of cardiac ailments.

REFERENCES:
patent: 3725393 (1973-04-01), Stache et al.
patent: 3801576 (1974-04-01), Stache et al.
patent: 4060607 (1977-11-01), Jarreau et al.

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