Amino-3-cardenolide derivatives, process for their preparation,

Details Amino-3-cardenolide derivatives, process for their preparation, Amino-3-cardenolide derivatives, process for their preparation,

1979-01-26

1980-08-12

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424241, C07J 1900, A61K 3158

Patent

active

042172802

ABSTRACT:
Amino-3-cardenolide derivatives represented by the general formula (I) ##STR1## wherein n and m, which may be the same or different, each represents an integer from 0 to 4; R.sub.1, R.sub.2, R.sub.4, R.sub.5 and R.sub.6, which may be the same or different, each represents a hydrogen atom or a hydroxy, alkoxy or acyloxy group; R.sub.3 represents a lower alkyl, aldehyde, haloalkyl, hydroxyalkyl, acyloxyalkyl, or ethylenedioxyalkyl group; R.sub.7 represents a hydrogen atom or an alkyl group; R.sub.8 represents a hydrogen atom or an alkyl, acyl, alkyloxycarbonyl or aralkoxycarbonyl group; R.sub.9 represents a hydrogen atom or an alkyl group; R.sub.8 and R.sub.9 can combine and form with the nitrogen atom a heterocyclic ring; R.sub.10 represents a hydroxy, alkoxy or aralkoxy group, an amino residue of amino acid or of an oligo-peptide, useful especially for the treatment of cardiac ailments.

REFERENCES:
patent: 3873379 (1975-04-01), Stache et al.
patent: 3901882 (1975-08-01), Meyer

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