Amines useful as brain imaging agents

Details Amines useful as brain imaging agents Amines useful as brain imaging agents

1980-06-19

1982-11-23

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Attached to antibody or antibody fragment or immunoglobulin;...

564373, 564374, 564384, A61K 4900, A61K 4300

Patent

active

043605117

ABSTRACT:
Certain radioiodine containing amines useful as brain imaging agents are disclosed. The compounds of the invention are represented by the formula ##STR1## wherein I is a radioisotope of iodine with I-123 being preferred, R is lower alkyl or halogen, R.sub.1 and R.sub.2 are the same or different and are selected from the group consisting of hydrogen and lower alkyl, R.sub.3 and R.sub.4 are the same or different and are selected from the group consisting of hydrogen, alkyl, aryl, substituted aryl, aralkyl, substituted aralkyl and substituted carbamoyl methyl or R.sub.3 and R.sub.4 taken together with the nitrogen to which they are attached form a 5- or 6-membered ring which may be substituted with one or more lower alkyl groups, x is 0 to 4, y is 0 to 3 and z is 0 or 1 and pharmaceutically acceptable acid addition salts thereof.

REFERENCES:
patent: 4021224 (1977-05-01), Pallos et al.
patent: 4048297 (1977-09-01), Counsell et al.
patent: 4053509 (1977-10-01), Faro et al.
patent: 4104383 (1978-08-01), Krausz
Blaschke et al., Chem. Ber., 108:2792 (1975).

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