Amines to sensitize multidrug-resistant cells

Details Amines to sensitize multidrug-resistant cells Amines to sensitize multidrug-resistant cells

1993-10-06

1995-07-25

Kumar, Shailendra

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544373, C07D40302

Patent

active

054363373

ABSTRACT:
The sensitizing amines of the present invention, illustrated by the steroidal amines (I) ##STR1## the alkyl amines (II), bicyclic amines (III), bicyclic ethers (IV), tricyclic compounds (V), indoles (VI) and various species are useful in treating individuals who have cancer has become resistant to cancer chemotherapeutic agents and in preventing the resistance from developing or slowing the rate of resistance to the chemotherapeutic agents.

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W. A. King et al., "Tumor-Associated Neurological Dysfunction Prevented by Lazaroids in Rats", pp. 112-115, J. Neurosurg., vol. 74, No. 1, Jan. 1991.

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