Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1975-12-19
1977-07-26
Demers, Arthur P.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
424322, 260240F, 424323, 424330, 260243B, 424324, 2602472A, 260268C, 26029376, 260307A, 26032643, 260348R, 260348A, 260349, 260465D, 260465E, 260470, 260471R, 260471C, 260479R, 260553R, 260553A, 260562A, 260559A, 260559B, 2605707, 260575, 260600R, 424246, 424248, 424267, 424272, 424274, 424309, 424317, 424319, C07C10312
Patent
active
040384144
ABSTRACT:
Amines of the formula ##STR1## wherein R.sub.1 is lower alkyl, lower alkoxy or amino, R.sub.2 is hydrogen or lower alkyl, R.sub.3 is hydrogen, lower alkyl, carboxyl or lower alkoxycarbonyl, R.sub.4 is hydrogen or lower alkyl, R.sub.5 is lower alkyl, aryl-lower alkyl or optionally functionally modified carboxy-lower alkyl and R.sub.6 denotes halogen, trifluoromethyl, lower alkyl, lower alkenyl, lower alkoxy, lower alkenyloxy, nitro, lower alkoxymethyl, carbamoyl, N-lower alkylcarbamoyl, nitrile, lower alkinyloxy or hydrogen, and their salts block cardiac and vascular .beta.-receptors the are useful in the treatment of arrhythenias and angina pectoris and as intermediates for, especially for pharmaceutically active substances.
REFERENCES:
patent: 3634511 (1972-01-01), Howe et al.
patent: 3712927 (1973-01-01), Howe et al.
patent: 3755413 (1973-08-01), Koppe et al.
patent: 3852468 (1974-12-01), Howe et al.
patent: 3864398 (1975-02-01), Suzuki et al.
patent: 3872147 (1975-03-01), Koppe et al.
Jaeggi Knut Alfred
Ostermayer Franz
Schroter Herbert
Ciba-Geigy Corporation
Demers Arthur P.
Groeger Theodore O.
Kolodny Joseph G.
Maitner John G.
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