Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Coated – impregnated – or colloidal particulate
Reexamination Certificate
2005-01-14
2009-06-02
Metzmaier, Daniel S (Department: 1796)
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Coated, impregnated, or colloidal particulate
C516S078000, C428S407000, C427S221000
Reexamination Certificate
active
07541017
ABSTRACT:
The invention relates to a composition comprising a colloid which is stable under physiological pH and ionic strength, said colloid comprising particles having a silica core and a shell: a) wherein said shell comprises a cross-linked poly(ethylene)imine polymer having amine functionalities; b) wherein the particles have a volume-weighted mean particle size diameter of less than 200 nm, and c) wherein greater than 50% of said polymer in the colloid is bound to the core surfaces, wherein the polymer having amine functionalities has an average molecular weight less than 100,000 g/mol, the composition has a H of between 6 and 8; and d) wherein the colloid contains between 300 and 6000 .μmol amine-monomer/g core particles.
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Bringley Joseph F.
Harder John W.
Hewitt James M.
Qiao Tiecheng A.
Wunder Andrew
Carestream Health Inc.
Metzmaier Daniel S
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