Amine derivatives

Details Amine derivatives Amine derivatives

1982-12-10

1987-11-10

Hines, Robert V.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

2605011, 564338, A61K 31455, C07C 8728

Patent

active

047058072

ABSTRACT:
Novel amines of formula:

REFERENCES:
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patent: 3308160 (1967-03-01), Snyder
patent: 3362878 (1968-01-01), Snyder
patent: 3413348 (1968-11-01), Gregory et al.
patent: 3742055 (1973-06-01), Freedman
patent: 3980785 (1976-09-01), Wildsmith
Roll et al., "Proton Magnetic Resonance Spectra and Stereochemistry of Some 5,6-Disubstituted Bicyclo [2.2.2]oct-2-enes," J. Pharm. Sci. 54 (8), 1110-1117 (1965).
P. N. Patil et al., "Molecular Geometry and Adrenergic Drug Activity," Pharmacological Reviews 26 (4), 323-334, 348-355 (1975).
Burger, "Medicinal Chemistry," vol. II, 3rd Ed., pp. 1471-1472, 1478-1480, 1490-1492, (1970).
Roos et al., "5-Hydroxyindolacetic Acid (and Homovanillic Acid Levels in the Cerebrospinal Fluid after Probenecid Application in Patients with Manic-Depressive Psychosis," Chem. Abstr. 71:79688c (1969).
Pullar, "Amine Metabolism in Affective Disorders," Biochem. Soc. Spec. Publ. 1, 97-100 (1973).
Papeschi et al., "Homovanillic and 5-Hydroxyindoleacetic Acid in Cerebrospinal Fluid of Depressed Adults," Arch. Gen. Psychiat. 25, 354-357 (1971).
Bunney et al., "Effect of L-Dopa on Depression," Lancet 1, 885-886 (1969).
Bunney et al., "L-Dopa in Depressed Patients," Lancet 1, 352 (1970).
Clark et al., "Drugs and Psychiatry: a New Era," Newsweek, Nov. 12, 1979, pp. 98-104.

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