Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1995-09-18
1998-03-03
Burn, Brian M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514668, 514670, 514844, 514845, 514873, 564506, 564507, A61K 3113
Patent
active
057234973
DESCRIPTION:
BRIEF SUMMARY
This application is a 35USC371 of PCT/JP94/00436, filed Mar. 17, 1994.
1. Technical Field
The present invention relates to an amine derivative which has excellent effects of preventing and smoothing or removing wrinkles, makes it possible to maintain the normal functions of the skin and moreover is useful for the prevention of dandruff and in improving the skin after sunburn, and an external skin care preparation (hereinafter referred to as "a dermatologic preparation") containing such an amine derivative.
2. Background Art
In recent years, it has been a matter of significant concern to maintain a healthy and beautiful skin irrespective of age or sex. However, the skin is delicately affected by temperature, humidity, ultraviolet rays, cosmetic compositions, aging, diseases, stress, eating habits and the like. Therefore, various troubles such as the decrement of various functions (functions of preventing the loss of water and the like from the vital body, controlling the homeostatic maintenance of the body heat, protecting the body from physical and chemical stimulation and various bacteria and keeping the resilience of the skin to determine its surface form, and the like) of the skin and aging of the skin occur.
Of these, wrinkles, which are one of dermal troubles, occur due to aging or dermal aging by sunlight. More specifically, cells for producing the fibrous tissue of the dermis are made small and lessened by exposure to sunlight or with the increase in age, and particularly, collagen fibers are lost to a great extent, and so the skin is aged by degeneration of the dermis, reduction of subcutaneous adipose tissue and the like, which forms the cause of wrinkles, relaxation and loss of resilience.
Various compositions and methods have heretofore been proposed for preventing or removing wrinkles caused by such an aging effect (Japanese Patent Application Laid-Open Nos. 185005/1987, 502546/1987, 72157/1990 and 288822/1990, etc.).
However, all of these proposals have not exhibited a satisfactory effect of preventing or smoothing wrinkles.
On the other hand, vulgaris cutaneous troubles such as xeroderma, fatty skin and seborrhea sicca in epidermis occur due to the functional aberration of skin tissue caused by intracorporeal and extracorporeal factors, which act on the vital body, such as changes of external environment (seasonal changes, ultraviolet rays, etc.) and variations in physiological functions (attendant on aging or a disease), dermal hypertrophy and parakeratosis induced thereby, etc.
In order to prevent and improve such cutaneous troubles, it has been attempted, for example, to apply a synthetic or natural humectant to the skin, thereby preventing the drying of the skin and enhancing the moistening ability of the skin, or to apply a blood-circulation-accelerating agent to the skin, thereby accelerating the circulation of blood.
However, these methods have involved various problems in respect of the preventing and improving effects on the various cutaneous troubles, persistency thereof, stability and safety of the agents used, and the like. That is, since these methods generally are intended to supply the water of the surface of the epidermis, in particular, of the horny layer, or a part of the humectant, the efficacy and effect thereof have been temporary, and so persistent improvement of the skin has been unable to be expected.
There has thus been a demand for development of a substance having excellent effects of preventing the occurrence of wrinkles and smoothing or removing the wrinkles and on the other hand, possessing marked inhibitory effects on parakeratosis of the skin, dermal hypertrophy, metabolic aberration of lipid and the like.
In view of the foregoing circumstances, the present inventors have carried out an extensive investigation. As a result, it has been found that a specific amine derivative, which will be described subsequently, exhibits marked effects of smoothing or removing wrinkles and improving keratinization, thus leading to completion of the present invention.
DISCLOSU
REFERENCES:
patent: 3891709 (1975-06-01), Higuchi et al.
patent: 4083872 (1978-04-01), Schwarze et al.
patent: 5552445 (1996-09-01), Ohashi et al.
Fujimori Taketoshi
Fujimura Tsutomu
Higuchi Kazuhiko
Imokawa Genji
Kawamata Akira
Burn Brian M.
Kao Corporation
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