Amine derivative

Details Amine derivative Amine derivative

2006-11-07

2006-11-07

Davis, Brian (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

Reexamination Certificate

active

07132573

ABSTRACT:
The invention relates to (1S)-1-isobutoxymethyl-3-methylbutylamine useful as an intermediate in the synthesis of sodium (2S,3S)-3-[[(1S)-1-isobutoxymethyl-3-methylbutyl]carbamoyl]oxirane-2-carboxylate and a process for production thereof. The process comprises reacting L-leucinol with a compound represented by the following formula in the presence of a base and reducing the obtained (1S)-1-(2-methyl-2-propenoxymethyl)-3-methylbutyl-amine:[in which X is a leaving group].

REFERENCES:
patent: 3640855 (1972-02-01), Bakker
patent: 3796756 (1974-03-01), Bakker
patent: WO-99/11640 (1999-03-01), None
International Search Report dated Oct. 21, 2003 Application No. PCT/JP03/11468.

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