Amine-containing porphyrin derivatives

Drug – bio-affecting and body treating compositions – Lymphokine

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514410, A61K 3140, A61K 3900

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active

051568403

ABSTRACT:
The invention relates to amine-containing porphyrin derivatives. Theporphyrins can be used as photosensitizers which are useful as therapeutic agents. Also described are methods for preparing conjugates in which a porphyrin derivative is covalently attached to an antibody or antibody fragment. In vivo therapeutic methods utilizing the conjugates are also desired.

REFERENCES:
Dougherty, 1983, in Porphyrin Photosensization, New York Plenum Publishing Corp. pp. 3-13.
Hasegawa et al., 1978, Chem. Abstracts 89(13): 29 Abstract No 1107732.
Mew et al., 1983, J. Immunol. 130(3): 1473-1477.
Ocampo et al., 1985, J. Chem. Soc. Commun. 4: 198-200.
Wat et al., 1984, Prog. Clin. Biol. Res. 170: 351-359.

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