Amine compounds, their production and use

Details Amine compounds, their production and use Amine compounds, their production and use

2007-08-14

2007-08-14

O'Sullivan, Peter G. (Department: 1621)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S438000, C514S464000, C514S602000, C514S603000, C514S630000, C514S654000, C514S655000, C546S329000, C549S074000, C549S443000, C564S084000, C564S085000, C564S086000, C564S087000, C564S088000, C564S089000, C564S092000, C564S196000, C564S373000, C564S378000

Reexamination Certificate

active

10645934

ABSTRACT:
A compound of the formula:wherein Ar is an aromatic ring assembly group which may be substituted or a fused aromatic group which may be substituted; X is (i) a bond, (ii) —S—, —SO— or —SO2—, (iii) C1-6alkylene, C2-6alkenylene or C2-6alkynylene, etc., (iv) —CO—O— or (v) —(CH2)p-X1—, —(CH2)p-X1—CH2)q-, —(CH2)r-CO—X1—, —SO2—NR8— or —(CH2)r-SO2—NR8— wherein X1is O or NR8, R8is H, a hydrocarbon group which may be substituted or an acyl, p is 0 to 5, q is 1 to 5, p+q is 1 to 5, and r is 1 to 4; Y is a divalent C1-6aliphatic hydrocarbon group optionally containing O or S, which may be substituted; R1and R2each is H or a lower alkyl which may be substituted, or R1and R2form a N-containing heterocyclic ring which may be substituted; Ring A is a benzene ring which may be further substituted; and Ring B is a 4- to 8-membered ring which may be further substituted, or a salt thereof has the effect of inhibiting amyloid-β protein production and/or secretion and is useful as a pharmaceutical composition for preventing and/or treating the neurodegenerative disease, etc.

REFERENCES:
patent: 5137901 (1992-08-01), Junge et al.
patent: 6103766 (2000-08-01), Romero et al.
patent: A-31189/89 (1989-09-01), None
patent: A 332064 (1989-09-01), None
patent: A 754455 (1997-01-01), None
patent: A 63-77842 (1988-04-01), None
patent: WO-A 92/15558 (1992-09-01), None
patent: WO-A 95/32967 (1995-12-01), None
patent: WO98/06691 (1998-02-01), None

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