Amine compounds, their production and use

Details Amine compounds, their production and use Amine compounds, their production and use

1995-11-21

1997-05-27

Grumbling, Matthew V.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514278, 514252, 514253, 514255, 5142275, 5142288, 5142312, 5142315, 5142318, 5142345, 5142348, 514307, 514311, 514314, 514316, 514317, 514331, 514213, 514218, 514357, 514290, 514430, 514465, 514466, 546 16, 546 17, 546 18, 546148, 544396, 544360, 544361, 544362, 544363, 544364, 544365, 544366, 544367, 544379, 544112, 544113, 544114, 544115, 544116, 544118, 544119, 544121, 544123, 544126, 544127, 544129, 544130, 544135, 544136, 544144, C07D22100, C07D21100, C07D29500, C07D24100, A61K 3144, A61K 3147, A61K 31

Patent

active

056332483

ABSTRACT:
A compound of the formula: ##STR1## wherein Ar.sup.1 and Ar.sup.2 independently represent an optionally substituted aromatic group; P and Q independently represent a divalent aliphatic hydrocarbon group having at least 2 carbon atoms and optionally having either oxygen or sulfur in the carbon chain; R.sup.1 and R.sup.3 independently represent --CO--R, --CONH--R (R represents a hydrocarbon group or a heterocyclic group) or a hydrocarbon group; R.sup.2 and R.sup.4 independently represent hydrogen or an alkyl group; R.sup.2 and R.sup.4 independently represent hydrogen or an alkyl group; R.sup.1 and R.sup.2 or R.sup.3 and R.sup.4, taken together with the adjacent nitrogen atom, may form a nitrogen-containing heterocyclic group; and j represents 0 or 1, or a salt thereof, has excellent GnRH-receptor antagonizing activity and is useful as a prophylactic and therapeutic agent for hormone-dependent and other diseases.

REFERENCES:
patent: 4650900 (1987-03-01), Lassen et al.
Journal of Medicinal Chemistry, vol. 34, No. 1 (1991) pp. 12-19.
Arch. Int. Pharmacodyn., vol. CVII, No. 2 (1956) pp. 194-201.

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