Amiloride-sensitive sodium channel and method of identifying sub

Details Amiloride-sensitive sodium channel and method of identifying sub Amiloride-sensitive sodium channel and method of identifying sub

1995-01-23

1997-12-02

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

436501, C07K 1447

Patent

active

056937563

ABSTRACT:
An amiloride sensitive sodium channel (ENAC) has been localized to the epithelium of tongue, including taste tissue. This discovery provides a method of identifying substances which stimulate or block salty taste in mammals. Alternatively spliced forms have also been identified.

REFERENCES:
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Palmer et al., "Amiloride-Sensitive Na Channels From the Apical Membrane of the Rat Cortical Collecting Tubule", Proc. Natl. Acad. Sci. USA 83:2767-2770 (1986).
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